CALL FOR PAPERS Mitochondrial Function/Dysfunction in Health and Disease Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity
نویسندگان
چکیده
Constance Tweedie, Caroline Romestaing, Yan Burelle, Adeel Safdar, Mark A. Tarnopolsky, Scott Seadon, Steven L. Britton, Lauren G. Koch, and Russell T. Hepple Muscle and Aging Laboratory, Faculty of Kinesiology, University of Calgary, Calgary Alberta, Canada; Departement de Kinesiologie, Universite de Montreal, Montreal, Quebec, Canada; Departments of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan; and Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
منابع مشابه
Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity.
Artificial selection in rat has yielded high-capacity runners (HCR) and low-capacity runners (LCR) that differ in intrinsic (untrained) aerobic exercise ability and metabolic disease risk. To gain insight into how oxygen metabolism may have been affected by selection, we compared mitochondrial function, oxidative DNA damage (8-dihydroxy-guanosine; 8dOHG), and antioxidant enzyme activities in so...
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